Breakthrough Fuels New Blood Disorder Therapies
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Researchers at Weill Cornell Medicine have revealed the detailed workings of a cell membrane protein called TMEM16F, which plays a crucial role in blood coagulation and other biological processes. The discovery could lead to new therapeutic strategies for blood coagulation disorders and other conditions.
Weill Cornell Medicine investigators have revealed the detailed workings of a cell membrane protein called TMEM16F. The protein plays a crucial role in blood coagulation, cancer, and other biological processes. By embedding the protein in artificial liposomes, the researchers were able to image its active and inactive structures at near-atomic-scale resolution. The study found that TMEM16F's rearrangement of cell membrane lipids enables platelet cells to clump together to make blood coagulate. The discovery could lead to new therapeutic strategies for blood coagulation disorders. The researchers were able to design drug molecules specifically to target the protein's key conformations.
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