Cervix-on-a-Chip Could Improve STI Prevention and Treatment
Researchers have developed an 'immune-capable cervix-on-a-chip' to study sexually transmitted infections, revealing how microbiome balance affects infection outcomes. The breakthrough could lead to new therapies and prevention strategies for STIs.
A team of researchers, led by Jason Gleghorn from the University of Delaware, has created a microphysiological system that replicates the human cervical environment. The 'cervix-on-a-chip' model allows for real-time observation of interactions between infections, the immune system, and the vaginal microbiome. The study found that protective bacteria can reduce infection risk, while imbalanced microbiomes worsen outcomes. This discovery could accelerate the development of new therapies, including probiotics. The model was tested with infections such as chlamydia and gonorrhea. The research has the potential to reshape how STIs are studied and treated.
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