Could Hyperactivating Cancer Growth Genes Help Treat Bowel Cancer?
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Researchers are exploring a new approach to treating bowel cancer by hyperactivating cancer growth genes, rather than inhibiting them. This involves using patient-derived organoids to study the genetic makeup of tumors and identify potential new treatments.
Bowel cancer is a significant global health issue, being the third most common cancer and second leading cause of cancer death worldwide. Current treatments include surgery, radiotherapy, chemotherapy, and immunotherapy, but nearly half of patients experience recurrence and develop treatment resistance. Researchers are investigating an alternative approach by hyperactivating cancer growth genes to push cancer cells over the edge. Dr. Vivian Li at The Francis Crick Institute is leading a project to identify whether this approach could be effective using patient-derived organoids. These organoids allow researchers to study the genetic makeup of individual tumors and how they develop over time. By understanding how genes shape cancer progression and treatment resistance, researchers hope to develop new and more effective treatments for bowel cancer.
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