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Five Psychedelics, One Pattern: Largest Brain Imaging Study of Psychedelics To Date Reveals a Surprising Neural Signature

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Five Psychedelics, One Pattern: Largest Brain Imaging Study of Psychedelics To Date Reveals a Surprising Neural Signature

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A large-scale study analyzed brain imaging data from 267 participants and found that five different psychedelics share a common effect on brain activity. The discovery could influence the development of new treatments for mental health conditions.

A team led by Danilo Bzdok at McGill University pooled brain imaging data from 11 studies across five countries, analyzing over 500 brain scans from 267 participants. The researchers found that despite their chemical differences, five psychedelics - psilocybin, LSD, mescaline, DMT, and ayahuasca - produced two consistent changes in brain activity. The first change was a weakening of internal connections within the brain's networks, while the second change was an increase in connectivity between different networks. This discovery could lead to new treatments for mental health conditions. The study was published in Nature Medicine and is the largest brain imaging analysis of psychedelics to date. The findings provide a more comprehensive understanding of how psychedelics affect the brain.

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