March Madness Upset Predictions: Best Sweet 16 Picks for 2026

The NCAA Tournament's Sweet 16 stage is set to begin, with several teams looking to pull off upsets. The Iowa Hawkeyes and St. John's Red Storm are among the teams with a chance to advance with upset victories.
The NCAA Tournament's second weekend is underway. The Iowa Hawkeyes face the Nebraska Cornhuskers, with Iowa looking to dominate the glass and force turnovers. St. John's Red Storm takes on the Duke Blue Devils, with St. John's aiming to limit Duke's offense and force turnovers. The Hawkeyes and Red Storm are considered underdogs but have a chance to pull off upsets. Iowa's slow pace and rebounding advantage could give them an edge. St. John's has done a great job limiting drive-and-kick opportunities and forcing turnovers, which could trouble Duke.
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