Reimagining The Tumor Battlefield: Advancing Human-Relevant Models In Cancer Metastasis Research
Researchers are developing human-relevant models to study cancer metastasis, including 3D cultures and organ-on-chip platforms. These models aim to bridge the gap between laboratory studies and patient outcomes, providing critical insight into metastasis biology and improving drug development.
Cancer metastasis is a major driver of cancer mortality worldwide. Researchers are turning to human-relevant models, such as 3D cultures and organ-on-chip platforms, to study metastasis. The U.S. Food and Drug Administration emphasizes the value of these models in drug development. A new ex vivo tumor model, 3MIC, enables researchers to observe how tumor cells respond to environmental stressors. The model reveals how interactions within the tumor microenvironment influence metastatic potential. The FDA's 2023 framework highlights the importance of accurate modeling of human tumor biology for therapeutic evaluation.
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