RSCI scientists develop ‘first of its kind’ artificial heart valve

Researchers at RCSI University of Medicine and Health Sciences have created an artificial mitral heart valve model designed to replicate the complex mechanical behavior of real heart valve tissue. The model, developed by the RCSI Tissue Engineering Research Group, is the first of its kind to incorporate multi-directional mechanical properties and withstand realistic heart pressures and blood flow, addressing limitations of previous synthetic valves. The new model allows precise control over tension and thickness of valve components, enabling effective opening and closing. It successfully functioned under physiological flow and pressure conditions during physical and digital tests, marking a significant advancement in the field, according to Dr Claire Conway, a lecturer in RCSI’s department of anatomy and regenerative medicine. Dr Sina Javadpour, first author of the study and a postdoctoral fellow at Trinity College Dublin, highlighted the model’s potential for studying valve diseases and testing repair strategies in a controlled environment. The research was funded through an RCSI Star Lectureship and the Research Ireland Frontiers for the Future Programme, with findings published in *Acta Biomaterialia*. The artificial heart valve model is now part of the public Heart exhibition at RCSI’s Humanarium, offering insights into mitral valve function and disease. This innovation could improve understanding of mitral regurgitation, a condition affecting millions globally, and support the development of new medical treatments.